transmission
Locate de novo, recessive and other variants that are transmitted from parents to offspring
1. Usage
% vtools_report transmission -h
usage: vtools_report transmission [-h] [--parents PARENTS PARENTS]
[--offspring OFFSPRING [OFFSPRING ...]]
[--denovo [DENOVO [DENOVO ...]]]
[--recessive [RECESSIVE [RECESSIVE ...]]]
[--inconsistent [INCONSISTENT [INCONSISTENT ...]]]
[-v {0,1,2}]
optional arguments:
-h, --help show this help message and exit
--parents PARENTS PARENTS
Names of parents, which should uniquely identify two
samples.
--offspring OFFSPRING [OFFSPRING ...]
Names of one or more offspring samples.
--denovo [DENOVO [DENOVO ...]]
A list of tables to store denovo variants for each
offspring. DeNovo variants are defined as offspring
variants that do not exist in any of the parents,
including the cases when the offspring have different
variants from what parents have at the same genomic
locations.
--recessive [RECESSIVE [RECESSIVE ...]]
A list of tables to store recessive variants for each
offspring. Recessive variants are defined as variants
that are homozygous in offspring, and heterozygous in
both parents.
--inconsistent [INCONSISTENT [INCONSISTENT ...]]
A list of tables to store variants for each offspring
that demonstrate mendelian inconsistencies, namely
variants that are not passed from parents to offspring
in a Mendelian fashion. Examples of inconsistent
variants include de novo variants, homozygous variants
in offspring with only one parental carrier, wildtype
offspring variants with a homozygous parent,
heterozygous offspring variants with two homozygous
parents, and more complicated cases when multiple
variants appear at the same sites.
-v {0,1,2}, --verbosity {0,1,2}
Output error and warning (0), info (1) and debug (2)
information to standard output (default to 1).